Enantioselective Alkynylzinc Addition to Carbonyl Compounds by Tf-based Sulfamide-amine Alcohol Catalysis

The new Tf-based sulfamide-amine alcohol 3a was found to be very effective in catalyzing the enantioselective alkynylzinc addition to both aromatic aldehydes and unactivated aromatic ketones without using another metal species under mild condition, providing up to 92% ee and 90% ee for aldehydes and ketones, respectively.