Advances in Peptide-Modified Liposome Targeted Drug Delivery System

OBJECTIVE To introduce the advances of peptide-modified liposome targeted drug delivery system.METHODS The relevant literatures in recent years were referred and summarized.RESULTS The advances of liposomes modified by arginine-glycine-aspartic(RGD) peptide,alanine-proline-arginine-proline-glycine(APRPG) peptide,cell-penetrating peptide(CPP),vasoactive intestinal peptide(VIP) were elaborated.Peptide-modified drug-loaded liposomes may increase the selectivity of drugs in vivo and reduce side effects of drugs to improve their therapeutic index.CONCLUSION Peptide molecules are a class of important bioactive substances to the body,which are applied in targeted drug delivery system by specific-combination of ligand-receptor with good values and application prospects.