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Design, synthesis, and evaluation of novel 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists.

Shilan Liu,Yinhui Liu,Hongmei Wang,Yili Ding,Hao Wu,Jingchao Dong,Angela Wong,Shu-Hui Chen,Ge Li,Manuel Chan,Nicole Sawyer,Francois G Gervais,Martin Henault,Stacia Kargman,Leanne L Bedard,Yongxin Han,Rick Friesen,Robert B Lobell,David M Stout

Bioorganic & Medicinal Chemistry Letters（2009）

Cited 20|Views48
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Abstract
A novel series of 3-amino-4-hydrazine-cyclobut-3-ene-1,2-diones as potent and selective CXCR2 chemokine receptor antagonists were identified.
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Key words
3,4-Dioxocyclobut-1-enyl-hydrazine,Antagonists,CXCR2,Chemokine receptor
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