[p-(Thienylcarboxamido)phenoxy]propanolamine derivatives as diuretic and .beta.-adrenergic receptor blocking agents
JOURNAL OF MEDICINAL CHEMISTRY(1986)
摘要
The synthesis of [[(thienylcarbonyl)amino]phenoxy]propanolamines and their beta-adrenergic blocking and diuretic activity are described. Structure-activity relationships demonstrated that ortho substitution of the phenoxy ring with an hydrogen or an ester function leads to compounds possessing both activities. Ethyl 2-[3-[(1,1-dimethylethyl) amino]-2-hydroxypropoxy]-5-[(2-thienylcarbonyl)amino]benzoate (3d) was selected as the most active compound for further investigation.
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关键词
adrenergic receptor
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