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CyclinD1和Ki-67在茉莉酸甲酯抑制人肝癌细胞HepG2增殖作用中的表达变化

Yong-gang LU,Jie ZHANG,Jing TAN,Yong-zhang GUO

Chinese Journal of Current Advances in General Surgery（2013）

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Abstract
目的:探讨CyclinD1、Ki-67蛋白在茉莉酸甲酯(MeJA)抑制人肝癌细胞HepG2细胞增殖过程中的表达变化.方法:免疫细胞化学检测HepG2细胞CyclinD1、Ki-67蛋白的表达.结果:MeJA作用HepG2细胞48h后,CyclinD1、Ki-67蛋白表达水平明显下降(P＜0.01).结论:MeJA通过下调CyclinD1、Ki-67蛋白表达,使细胞周期相关蛋白的表达发生改变,减少处于增殖期的细胞数目,从而发挥抗肝癌作用.
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Key words
Liver neoplasms.HepG2 human hepatocellular carcinoma cell.CyclinD1 Protein.Ki-67 Protein.Methyl Jasmonate
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