Relationship between serum uric acid and hypertensive left ventricular hypertrophy

Objective To investigate the relationship between serum uric acid and hypertensive left ventricular hypertrophy(LVH).Methods From January 2006to December 2011,804hypertensives with or without anti-hypertensive treatment including 392males and 412females from the first affiliated hospital of Fujian medical university were enrolled.Based on the diagnostic criteria of LVH[left ventricular mass index(LVMI)≥125(male)or ≥120g/m2(female)],the patients were divided into two groups:hypertension with LVH group(LVH group,n=181)and hypertension without LVH group(non-LVH group,n=623).Patients were also stratified according to their blood pressure control status and ages.LVMI was determined by echocardiography.Serum uric acid was measured by the oxidase method.The association between serum uric acid and hypertensive LVH was analyzed by Pearson correlation analysis and multiple linear regression analysis.Results Pearson correlation analysis showed that the age,pulse pressure,serum uric acid level,and low density lipoprotein cholesterol(LDL-C)were positively correlated with the LVMI(r=0.143,0.167,0.187,0.190,respectively;all P0.05).In young/middle-aged(20-65years old)and elderly patients(≥65years old),for those without well blood pressure control,pulse pressure and serum uric acid were positively correlated with LVMI(young/middle-aged:r=0.220,0.239;and elderly:r=0.224,0.233,all P0.05)and for those with well blood pressure control,only the serum uric acid was positively correlated with LVMI(young/middle-aged:r=0.244,elderly:r=0.171,all P0.05).Multiple linear regression analysis showed that the age,pulse pressure,serum uric acid level and LDL-C of the patients were influencing factors for LVH(all P0.05),only pulse pressure and serum uric acid level were influencing factors for LVH in patients without well blood pressure control(all P0.05).Conclusion Serum uric acid is correlated with LVH independent of blood pressure.