Imidazo[1,2]hetarylglyoxylates: Synthesis and Reactivity toward Nucleophiles
SYNTHESIS-STUTTGART(2010)
Abstract
A practical approach to imidazo[1,2]hetarylglyoxylates via Friedel-Crafts acylation of the parent fused imidazoles with ethyl oxalyl chloride is reported. The reaction is strongly influenced by the electron-donating properties of the starting heterocycle. The generated imidazo[1,2] hetarylglyoxylates undergo standard transformations typical of alpha-keto esters upon reaction with various nucleophiles. All the products contain an imidazoheterocyclic scaffold which is considered a privileged structure for drug discovery.
MoreTranslated text
Key words
imidazoheterocycles,acylation,glyoxylates,privileged scaffolds
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined