Preparation and lab evaluation of a new denture adhesive

To develop a new kind of denture adhesive (DA), then to evaluate its mechanical and chemical properties, polyethylene oxide, methyl cellulose, sodium alginate, and cellulose ether, were viewed as four main factors, which would affect bonding load of DA, while two levels of each component were differentiated. Following table L 12 (2 11 ), twelve different formulae were designed by orthogonal design and bonding load values were recorded. According to bonding load of each formula, the optimized formula was selected out as this new adhesive material, Comfort-DA II. The changing of bonding load values of Comfort-DA II marinating in artificial saliva were measured, and an existing product, Protefix and Comfort-DA, were used as controls. Following initial load readings, samples and controls were measured from 1- to 12- hour intervals, respectively. Comfort-DA II was diluted at 1.0%, 2.0%, 3.3%, 5.0%, and 10.0% concentrations, and pH values were measured at 1-, 2-, 3-, 4-, 5-, 6-, and 8-hour intervals. Comfort-DA II presented as a pale-yellow paste. Group 6 gained the highest bonding load value of [193.8 (4.2)] N. The mean bonding load of Comfort-DA II was statistically different to Comfort-DA ( p = 0.004) and Protefix ( p = 0.006). Comfort-DA II exhibited a progressive increase in pH value over time and was slightly alkaline. Comfort-DA II showed significantly elevated mechanical and chemical properties, comparing to Comfort-DA. The results also indicate that orthogonal design may be an efficacious way to develop new dental materials.