Synthesis And Antiviral Activity Of Prostaglandin-J(1) Methyl Ester

A prostaglandin-F(1)alpha methyl ester derivative (12) possessing three different protecting groups on the hydroxy units was prepared so as to allow selective removal of the group attached to the 11-OH group. Compound (12) was converted into prostaglandin-J(1) methyl ester (16) in two steps (77% overall yield). Prostaglandin-J(1) methyl ester showed potent activity against Sendai virus.