Synthesis And Antiviral Activity Of Prostaglandin-J(1) Methyl Ester
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1(1999)
摘要
A prostaglandin-F(1)alpha methyl ester derivative (12) possessing three different protecting groups on the hydroxy units was prepared so as to allow selective removal of the group attached to the 11-OH group. Compound (12) was converted into prostaglandin-J(1) methyl ester (16) in two steps (77% overall yield). Prostaglandin-J(1) methyl ester showed potent activity against Sendai virus.
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