Efficacy and safety of domestic low-dose amphotericin B for invasive fungal infection in hospital

OBJECTIVE To discuss the efficacy and safety of domestic low-dose amphotericin B for invasive fungal infection in the hospital(invasive fungal infection,IFI). METHODS IFI 78 patients were given amphotericin B treatment,the initial dose of the 3 d 1,3,5 mg,5% glucose solution,50 ml,maintaining a speed of 5ml/h,an increase from 4 d to start his daily 5 mg,until 25 mg,then maintained the dose after wards.Course of treatment is 1 to 5 months,the total dosage is 1~1.5 g. RESULTS Of totally 78 strains of fungi,Candida albicans accounted for 61.5%,C.tropicalis accounted for 16.7%,smooth C.albicans 7.7%,C.parapsilosis accounted for 5.1%,C.krusei 3.9%,Fungi 5.1%,1 week after the end of treatment efficacy evaluation,10 cases recovered,51 cases markedly,progress in 8 cases,9 cases invalid,1 case death,the total effective rate was 78.2%,66 cases of fungal clearance,did not clear the 12 cases,clearance rate was 84.6%.33 cases of adverse reactions,adverse reaction rate was 42.3%.A total of 33 patients,61 adverse events occurred,which 1 species occurring adverse reactions in 14 cases,12 cases 2,3 in 5 cases,2 cases of 4.Hypokalemia,renal dysfunction,liver dysfunction,phlebitis,and the incidence of chills,fever and were 33.3%,17.9%,12.8%,6.4% and 7.7%,respectively. CONCLUSION China-made low-dose amphotericin B has good clinical efficacy IFI,fungal clearance rate on the same time,hypokalemia and renal function monitoring,to a certain extent,is still safe.