Fatal copper storage disease of the liver in a German infant resembling Indian childhood cirrhosis
Virchows Archiv. A, Pathological anatomy and histopathology(1987)
Abstract
A female child of non-consanguineous, healthy German parents fell ill at the age of 7 months with a progressive liver disease leading to irreversible hepatic failure 3 months later. Histological examination revealed severe liver cell necrosis, excessive Mallory body formation and veno-occlusive-like changes associated with massive storage of copper, similar to Indian childhood cirrhosis (ICC). Chronic copper contamination of drinking water was the only detectable aetiological factor. The study illustrates that ICC most probably is an environmental disease, also occurring outside the Indian subcontinent, and is likely to be underdiagnosed in the Western world.
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Key words
Liver,Copper storage,Indian childhood cirrhosis
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