CK19和Galectin-3对甲状腺乳头状微小癌早期诊断和治疗的意义
Chinese Journal of Diagnostic Pathology(2009)
Abstract
目的分析CK19和Galectin-3在甲状腺乳头状微小癌(PMCT)中的表达状况,了解这两种抗体组合对PMCT的早期诊断及鉴别诊断的临床价值,并探讨临床手术术式的选择及预后。方法采用免疫组化方法检测23例中CK19和Galectin-3的表达情况,并术后随访2~72个月。结果CK19和Galectin-3在23例PMCT中阳性表达率分别为91.31%和95.66%,23例患者中行患侧甲状腺腺叶或次全切除15例,双侧甲状腺腺叶切除6例,患侧甲状腺全切加峡部加对侧甲状腺次全切除2例;随访观察,除2例失访,其余21例患者均健在无复发或死亡。结论CK19和Galectin-3对PMCT的早期诊断及与甲状腺良性病变的鉴别诊断具有显著作用。PMCT预后较好,对于偶然发现或低危的PMCT可行甲状腺腺叶或甲状腺次全切除术,并保持临床长期随访观察。
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Key words
CK19,Papillary microcarcinoma,Galectin-3,Prognosis,Thyroid,Surgical management
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