Gender bias in autoimmune diseases
Journal of the Neurological Sciences(2009)
摘要
The majority of autoimmune disorders are characterized by female predominance. Several mechanisms have been proposed as explanations for this gender bias, among them X chromosome inactivation. An increased frequency of skewed X inactivation has been found in some autoimmune disorders, like scleroderma and autoimmune thyroid disease, and may thus offer a possible explanation for the female predominance.
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关键词
Autoimmunity,Multiple sclerosis,X chromosome,X chromosome inactivation
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