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The identification of structurally novel, selective, orally bioavailable positive modulators of mGluR2

Pier L. D’Alessandro,Corrado Corti,Adelheid Roth,Annarosa Ugolini,Anna Sava,Dino Montanari,Federica Bianchi,Stephen L. Garland,Ben Powney,Emma L. Koppe,Magalie Rocheville,Greg Osborne,Paloma Perez,Jesús de la Fuente,Maite De Los Frailes,Paul W. Smith,Clive Branch,David Nash,Stephen P. Watson

Bioorganic & Medicinal Chemistry Letters（2010）

Cited 24|Views28
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Abstract
The optimisation of an HTS hit series (1) leading to the identification of structurally novel, selective, orally bioavailable mGluR2 positive modulators GSK1331258 and GSK1331268 is described.
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Metabotropic glutamate receptor ligand,Metabotropic glutamate receptor,Positive allosteric modulator,mGluR,mGlu,mGluR2
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