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Convenient biological assay for polyethylene glycol-interferons in patients with hepatitis C.

Anne Boulestin,Nassim Kamar,Florence Legrand-Abravanel,Karine Sandres-Saune,Laurent Alric,Jean-Pierre Vinel,Lionel Rostaing,Jacques Izopet

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY（2004）

Cited 6|Views6
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Abstract
The vesicular stomatitis virus cytopathic effect reduction assay is suitable to quantify polyethylene glycol-alpha interferon 2a (PEG-IFN-alpha2a) and PEG-IFN-alpha2b. Human serum and ribavirin did not interfere with the assay. This bioassay was successfully used for assaying PEG-IFN-alpha2a and PEG-IFN-alpha2b in serum samples from patients undergoing combination therapy.
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Key words
cell line,recombinant proteins,biological assay
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