Effect of Melatonin on Genes Including FGF5 That Related to Hair Growth in Cashmere Goat Skin

The aim is to study the effect of melatonin on genes which related to hair growth on skin,and explore the mechanism of melatonin in cashmere growth.Using the Inner Mongolia white cashmere goats as the research object,10 lambs on 4 months age with similar body condition were selected,and divided into 2 groups randomly.Following testing requirements,the treatment group was implanted melatonin in subcutaneous behind the ear every two months according to 2mg / kg BW(body weight) dose,and nothing to the control.The experiment time was last for one year.Then the cashmere goat skin and hair in the body side were gathered,using real-time PCR to detect the expression changes of 9 genes related to hair growth.The results showed that(1)melatonin implanting can up-regulate FGF5's expression significantly(P0.0001),but has no significantly effect to β-catenin,MSX-2,Wnt10b,BMP2,BMPRⅠB,NTRK3,Delta1and hairless(P0.05);(2) melatonin implanting obviously improved the correlation between FGF5 and hairless,and make the negative correlation turn to positive correlation on β-catenin and NTRK3,the correlation with Wnt10b was reduced,while the other 4 were little changed.These results indicated that Melatonin up-regulate the expression of FGF5 in cashmere goat skin,impact the correlation of FGF5 with hairless,β-catenin and NTRK3;the impact of melatonin on hair is different with other animals;the effect of melatonin on complex organizational and individual cells are different.MAPK signaling pathway is the greatest impacted by melatonin.It is putative that melatonin can regulate RORα in cashmere goat skin to impact the correlation of FGF5 with hairless,β-catenin,NTRK3 and Wnt10b,and inhibit the function of MSX2 and BMP2 for promoting hair growth.