The plasma levels of Aβ1-40 and Aβ1-42 in Uyghur patients with normal tension glaucoma

• Aim: To assess the role of β amyloid protein in pathogenesis of normal tension glaucoma by analyzing the level difference of Aβ 1-40 and Aβ1-42 in the plasma between Uyghur patients with normal tension glaucoma and control groups. • Methods: Aβ1-40 and Aβ1-42 were assayed in 37 cases of Uyghur normal tension glaucoma patients, 40 cases of Han nationality normal tension glaucoma patients and 40 cases of Uyghur cataract patients by using ELISA method. • Results: Aβ1-40 and Aβ1-42 concentrations in Uyghur and Han nationality normal tension glaucoma groups and Uyghur cataract group were (142.4 ±7.0)ng/L, (140.0 ±4.2)ng/L, (120.3±5.3)ng/L and (159.8±5.5)ng/L, (161.1±2.8) ng/L, (101.6±6.5)ng/L, respectively. The mean concentrations of Aβ1-40 and Aβ1-42 in Uyghur normal tension glaucoma group were significantly higher than those of cataract group (P< 0.05). There were no significant differences between Uigur normal tension glaucoma group and Han nationality normal tension glaucoma group (P>0.05). • Conclusion: The levels of Aβ1-42 and Aβ 1-42 in the plasma of Uyghur patients with normal tension glaucoma were higher than that of Uyghur cataract group, but were not correlated with races of Uyghur or Han nationality.