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排名必读论文期刊顶会热点AI 简史溯源树小脉星探人才迁徙塔尖人才国防情报追踪开源工具智慧手语
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Structure based evolution of a novel series of positive modulators of the AMPA receptor.

Craig Jamieson,John K F Maclean,Christopher I Brown,Robert A Campbell,Kevin J Gillen,Jonathan Gillespie,Bert Kazemier,Michael Kiczun,Yvonne Lamont,Amanda J Lyons,Elizabeth M Moir,John A Morrow,John Pantling,Zoran Rankovic,Lynn Smith

Bioorganic & Medicinal Chemistry Letters（2011）

引用 29|浏览16
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摘要
The evolution of an advanced lead compound 19 through a scaffold hopping approach guided by structure-based drug design is described.
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关键词
AMPA receptor,Allosteric modulator,SBDD,Indane,Scaffold hopping
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