Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists
Bioorganic & Medicinal Chemistry Letters（2010）
Abstract
Medicinal chemistry efforts have identified a quinolinone class of potent NPSR antagonists that readily cross the blood–brain barrier. Optimization efforts resulted in the identification of a potent NPSR antagonist which dose-dependently and specifically inhibited 125I-NPS binding in the CNS when administered to rats.
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Key words
Neuropeptide S receptor
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