5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.

Nicholas Simon Stock,Christopher Baccei,Gretchen Bain,Charles Chapman,Lucia D Correa,Janice Darlington,Christopher King,Catherine Lee,Daniel S Lorrain,Pat Prodanovich,Angelina M Santini,Kevin Schaab,Jilly F Evans,John Howard Hutchinson,Peppi Prasit

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

Dermal application of the potent FLAP inhibitor, 6 (AM643) using a prototypical vehicle in a murine ear arachidonic acid model showed significant reduction in the concentrations of leukotrienes in mouse skin with concomitant reduction in ear swelling.

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关键词

Leukotrienes,FLAP,Inhibitor

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