A single-pot synthesis of 1,1,2-trisubstituted 1,2-dihydronaphthalenes in high enantiomeric purity
Tetrahedron Letters(1994)
Abstract
A diastereoselective addition of Grignard reagents to nonracemic 2-(1-naphthyl)-4-(4R)-phenyl-1,3-oxazolidines (1) followed by electrophilic trapping of the azaenolate is described. This tandem addition was performed in a single flask producing 1,1,2-trisubstituted 1,2-dihydronaphthalenes 7 in excellent yields and high enantioselectivities.
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Key words
synthesis,single-pot
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