Entry into a new class of protein kinase inhibitors by pseudo ring design.
Bioorganic & Medicinal Chemistry Letters(2008)
摘要
A pyrimidin-4-yl-urea motif forming a pseudo ring by intramolecular hydrogen bonding has been designed to mimic the pyrido[2,3-d]pyrimidin-7-one core structure of a well-established class of protein kinase inhibitors. Potent inhibition of a number of protein kinases was obtained with the first prototype compound synthesized to probe the design concept.
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关键词
Kinase,Scaffold morphing,Pseudo ring
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