Production of 117mSn with high specific activity by cyclotron

Applied Radiation and Isotopes(2011)

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摘要
A method to produce 117mSn radionuclide using accelerator production route is described. A new method is proposed to separate the 117mSn. Specific activities and thick target yield for 116Cd(α,3n)117mSn reaction at Eα=35MeV bombarding energy were determined. The estimated production yield of 117mSn was 37.5kBq/μAh for 13.16mg/cm2 natural cadmium-oxide target and 410kBq/μAh for 11.07mg/cm2 highly enriched (95%) 116CdO target. The method developed for separation of 117mSn from Cd using anion-exchange resin (Dowex −1×8, fluorine form, 400mesh) can achieve 98% radiochemical yield of 117mSn with more than 99% radionuclidic purity. The estimated specific activity is 2.4GBq/mg that can be reached with the used irradiation conditions.
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关键词
Enriched 116Cd,117mSn,Alpha irradiation,High specific activity,Radiochemical separation,Radionuclide therapy
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