Asymmetric Reduction Of Ketones Using Lia1h4 Modified With Chiral 1,2-Aminodiols

Four chiral aminodiols from ring opening of ( S )-propylene oxide and ethylene oxide wiht n-butylamine and ( R ) or ( S )-α-methylbenzylamine were used to modify LiAlH 4 . Assymetric reduction of acetophenone and propiophenone gave the highest percent enantiomeric excess when the modifier was made from ( S )-oxide and ( S )-amine.