Application of lidocaine and atropine in painless colonoscopy

Objective:To observe the cardiovascular response in painless colonoscopy and the prevention effects of propofol injection pain when lidocaine composited with atropine were used in this process.Methods:Sixty patients at ASA grade 1 or 2 that chose to underwent painless colonoscopy were randomly divided into control group(group A,n=30),and lidocaine composited with atropine group(group B,n=30).Patients in group A were given injection of propofol(1~1.5 mg/kg)and fentanil(0.5 μg/kg)directly,while Group B were given intravenous injection of lidocaine(1 mg/kg)and atropine(0.01 mg/kg)3 minutes prior to the propofol(1~1.5 mg/kg)and fentanil(0.5 μg/kg)injection 3 min later.Results:In group A,patients' MBP significantly decreased when the fiber enteroscopy was inserted(T2)and the third minute(T3)of observation comparing with that before the surgery(P0.01),HR also significantly decreased at T3(P0.05).However,increace of patients' MBP and HR in group B at the corresponding time points were insignificant(P0.05)indicating propofol injection pain was alleviated significantly.Conclusion:Lidocaine composited with atropine can alleviate the cardiovascular response and prevent injection pain of propofol during colonoscopy.