氟西汀和5-羟色胺对肉鸡肺动脉平滑肌细胞增殖与凋亡的影响
Animal Husbandry & Veterinary Medicine（2011）
Abstract
为探讨5-羟色胺转载体(5-HTT)在肉鸡肺动脉高压综合征发病中的机制,采用MTT比色法、流式细胞术及Hoechst33258荧光染色法研究5-羟色胺(5-HT)和5-HTT抑制剂氟西汀对体外培养的肉鸡肺动脉平滑肌细胞(PASMC)增殖与凋亡的影响,发现氟西汀能够抑制5-HT促PASMC增殖的作用;氟西汀能明显促进PASMC的凋亡,但氟西汀和5-HT共同作用于细胞,PASMC凋亡率明显少于氟西汀单独处理组。表明5-HTT在调节肉鸡PASMC的增殖和凋亡方面起重要作用,有可能参与肺动脉高压肉鸡肺血管重构的形成。
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Key words
serotonin,pulmonary artery smooth muscle cell of broiler,serotonin transporter,fluoxetine
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