Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: orally active prostacyclin mimetics. Part 6.
Bioorganic & Medicinal Chemistry Letters(2006)
Abstract
The synthesis and biological activity of novel derivatives of our previously reported IP receptor agonist FR181157, replacing the cyclohexene-linker, is described. Compound 1i (FR207845) was identified as a potent non-prostanoid PGI2 mimetic with a good oral bioavailability.
MoreTranslated text
Key words
Prostacyclin,PGI2,IP receptor,Agonist
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined