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Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: orally active prostacyclin mimetics. Part 6.

Akira Tanaka,Kouji Hattori,Kiyoshi Taniguchi,Osamu Okitsu,Seiichiro Tabuchi,Mie Nishio,Yasunori Nagakura,Noriaki Maeda,Hidetsugu Murai,Jiro Seki

Bioorganic & Medicinal Chemistry Letters（2006）

Cited 7|Views17
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Abstract
The synthesis and biological activity of novel derivatives of our previously reported IP receptor agonist FR181157, replacing the cyclohexene-linker, is described. Compound 1i (FR207845) was identified as a potent non-prostanoid PGI2 mimetic with a good oral bioavailability.
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Key words
Prostacyclin,PGI2,IP receptor,Agonist
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