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Water-soluble propofol analogues with intravenous anaesthetic activity.

A Cooke,A Anderson,K Buchanan,A Byford,D Gemmell,N Hamilton,P McPhail, S Miller,H Sundaram,P Vijn

Bioorganic & Medicinal Chemistry Letters（2001）

Cited 20|Views22
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Abstract
Propofol (2,6-diisopropylphenol) is a widely used intravenous anaesthetic that is formulated as an emulsion since it lacks water solubility. We report a range of water-soluble analogues of propofol, containing a para-alkylamino substituent, which retain good intravenous anaesthetic activity in rodents.
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water soluble
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