3-Thio-quinolinone maxi-K openers for the treatment of erectile dysfunction

A series Maxi-K openers for the treatment of erectile dysfunction based on the 3-thio-quinolinine core is described. Significant levels of channel opening (up to 550% of control) are seen in transfected oocytes. Functional activity in rabbit corpus cavemosum tissue strips confirms the potential to effect therapy for ED, the effect being maximal for the 3-amino-2-hydroxy thiol side chain.