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狼疮性肾炎中ANCN及其靶抗原的临床研究

任岳钦,马云航,李延国, 王世明

JOURNAL OF SHANDONG MEDICAL COLLEGE（2006）

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Abstract
目的 探讨狼疮性肾炎(LN)患者血清中抗中性粒细胞胞浆抗体(ANCN)及其靶抗原的表达及临床意义.方法 收集103例LN病人血清,分别用间接免疫荧光法(IIF)及免疫酶联吸附实验(ELISA)法检测ANCA的阳性率及其靶抗原的表达率.结果 活动期LN的ANCA阳性率及靶抗原的表达率均高于稳定期LN,且以组蛋白酶G (CG)及乳铁蛋白(LF)为主,活动期LN中抗dsDNA、低补体血症、血沉增快及肾功能下降的发生率均明显高于稳定期.结论 LN患者血清中ANCN阳性及靶抗原的表达与LN的活动有关,肾脏损害以ANCA阳性者为重.
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Antibody Engineering
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