Design and synthesis of 2-oxo-imidazolidine-4-carboxylic acid hydroxyamides as potent matrix metalloproteinase-13 inhibitors

Ralph P Robinson,Ellen R Laird,Kathleen M Donahue,Lori L Lopresti-Morrow,Peter G Mitchell,Matthew R Reese,Lisa M Reeves,Amber I Rouch,Ethan J Stam,Sue A Yocum

Bioorganic & Medicinal Chemistry Letters（2001）

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摘要

A novel series of imidazolidinone-based matrix metalloproteinase (MMP) inhibitors was discovered by structural modification of pyrrolidinone 1a. Potent inhibition of MMP-13 was exhibited by the analogues having 4-(4-fluorophenoxy)phenyl (4a, IC50=3nM) and 4-(naphth-2-yloxy)phenyl (4h, IC50=4nM) as P1′ groups.

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matrix metalloproteinase

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