Comparative research between the MRI and pathological sections on limb soft-tissue aggressive fibromatosis in 25 cases

Objective To observe the pathological characteristics and the edge integrity of soft-tissue aggressive fibromatosis,providing theoretical basis for the safe margin and range in tumor operation.Methods Pathological sections for 25 patients with soft-tissue aggressive fibromatosis were stained by HE,Masson and immunohistochemistry(Vimetin,actin and HHF35).MRI scan was carried out to observe aggressive biologic behavior of fibromatosis.Results The average diameter of tumor was 5.6 cm and the border of most tumor(92%) was not clear.Aggressive soft-tissue fibroma was origin from skeletal muscle and 92%(23/25) of them with lobulated edge.All tumors showed infiltration growth and mitoses.Conclusion Combining MRI and pathological feature,comprehensive pathological examination could accurately reflect the size of aggressive fibromatosis,the degree of tumor invasion and provide the effective basis for clinical therapy.