Ischaemic preconditioning of rat myocardium: effects on postischaemic coronary endothelium hyperpermeability and microcirculatory damage

P. Di Napoli,Contegiacomo G,A. Di Crecchio,P. Tiloca,Taccardi Aa,Maggi A,Barsotti A

Journal of clinical and basic cardiology（1998）

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摘要

everal experimental and clinical studies [1–5] performedin the last ten years have shown the cardioprotective effectsof short cycles of ischaemia and reperfusion against reperfusioninjury; this phenomenon has been termed preconditioning(P). Various pathophysiological mechanisms have been hypo-thesised to explain this phenomenon and it is generally thoughtto have a multifactorial genesis.

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关键词

endothelial permeability,ischaemia-reperfusion damage,endothelium,preconditioning,microcirculation,schema,cardiac output,histology,creatine kinase,protocol,enzyme,blood flow,design,systolic blood pressure

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