Observation of fuvastatin on early stage diabetic nephrosis

Objective To explore the effect of fuvastain on early stage diabetic nephrosis,and to study its mechanism in the treatment.Methods Sixty patinents with early stage biabetic nephrosis were randomly dived into 2 groups.The control group(n=30)was treated with diabetic diet,controling glucose etc.The treatment group(n=30)was treaed with fuvastain(40mg,po,qn)on the basis of the control group.Then UAER,Scr,CRP were compared after 3 months and before treatment.Results The UAER,Scr,and CPR in the treatment groups were significantly decreased compared to before treatment,and the UAER and CPR in the treatment were significantly decreased to the control group too.Howerer,the UAER,Scr and CRP in the control groups wasn′t significantly decreased compared to before treatment.Conclusion Because fuvastain can reduce the CRP,so the effect of resisting inflammation can lower the trace albuminueia,and improve the kidney′s function.The effect is not dependent on the effect of fuvastain reducing lipid.