Potential antineoplastics I: substituted 3,5-dioxo-and 3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazines.

Ibrahim el-SA,S A Shams el-Dine,F S Soliman,I M Labouta

Journal of Pharmaceutical Sciences（1979）

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摘要

The synthesis of some 6-substituted 3,5-dioxo- and 3-thioxo-5-oxo-2,3,4,5-tetrahydro-1,2,4-triazines for possible antineoplastic activity is reported. The assigned structures were substantiated by IR, NMR, and mass spectral studies of representative members of the series. Four compounds were tested against P-388 lymphocytic leukemia and were inactive.

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关键词

1,2,4-Triazines, substituted—synthesized, antineoplastic activity evaluated in mice,Antineoplastic activity—various substituted 1,2,4-triazines evaluated in mice,Structure–activity relationships—substituted 1,2,4-triazines evaluated for antineoplastic activity in mice

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