The study on relationship between cigarette smoking and the p53 protein and P21 protein expression in non-small lung cancer
Chinese Journal of Cancer Research(2013)
Abstract
This paper discusses the relationship between cigarette smoking and the p53 protein and P21 protein expression by the immunohistochemical
analysis in 93 cases with lung cancer in which squamous cell carcinoma accounted for 45 cases, adenocarcinoma 48 cases. The
results showed that positive proportion of p53 protein expression was 74.20% (28 or 37 squamous cell carcinoma, 21 of 30 adenocarcinomas)
in cigarette smoking group with lung cancers, and 38.46% (3 of 8 squamous cell carcinoma, 7 of 18 adenocarcinomas) in nonsmoking
group with lung cancers. The difference was statistically significant. Odds ratio was 4.14 and confidence limits for OR was
1.42–12.52. A dose-related presents in the p53 protein expression for the smoking amount and smoking years. The positive proportion
of P21 protein expression was 79.31% (21 of 28 squamous cell carcinoma, 25 of 30 adenocarcinomas) in cigarette smoking group
with lung cancers, and 82.75% (10 of 11 squamous, 14 of 18 adenocarcinomas) in nonsmoking group with lung cancers, the difference
was not statistically significant. But their positive proportion of P21 protein expression were very high in both groups.
It was indicated that no relationship between cigarette smoking and the P21 protein expression. We suggest that the p53 gene
could be a common target of tobacco-associated carcinogenesis in lung cancer.
MoreTranslated text
Key words
protein expression,confidence limit,statistical significance,odd ratio
AI Read Science
Must-Reading Tree
Example
![](https://originalfileserver.aminer.cn/sys/aminer/pubs/mrt_preview.jpeg)
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined