Study of repairing of radius defects hybridized RP scaffold

Objective To observe the effects of hybridized RP scaffold on repairing segmental bony defects.Methods BMSCs were seeded into the hybridized and original RP scaffold to repair 15 mm segmental defect in the radius of rabbits.Radiograph,the scaffold degrading rate and new bone formation were evaluated by Micro CT and histology.Results The results suggested that the apatite/collagen sponge composite coating could improve the RP scaffold degrading rate and new bone forming in vivo.Bony union was observed in experimental group 1 year after the operaion.Conclusion The PLGA/β-TCP scaffold with apatite/collagen sponge composite coating is promising as a candidate 3-D substrate for bone tissue engineering.