Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: Synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis
Bioorganic & Medicinal Chemistry Letters(2011)
Abstract
The synthesis, structure–activity relationships (SAR) and biological evaluation of thiazole based tricyclic inhibitors of IKK2 are described. Compound 9 was determined to be efficacious in a murine model for rheumatoid arthritis.
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Key words
IKK,IKK2,IKKβ,NF-κB
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