ChemInform Abstract: A Stereoselective Synthesis of Dinucleotide Phosphorothioates, Using Chiral Indol-oxazaphosphorine Intermediates.
Cheminform（2010）
Abstract
A stereoselective synthesis of dinucleotide phosphorothioates with a de of > 98%, using (S) and (R)-3-hydroxy-4-(2-indolyl)butyronitrile 3b as chiral auxiliaries, is reported. The procedure may be adaptable to solid phase synthesis. (C) 1997 Elsevier Science Ltd.
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Key words
nucleic acids
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