Non-Peptide αvβ3 antagonists. Part 3: Identification of potent RGD mimetics incorporating novel β-Amino acids as aspartic acid replacements

Potent non-peptidic αvβ3 antagonists have been prepared incorporating various β-amino acids as aspartic acid mimetics. Modification of the β-alanine 3-substituents alters the potency and physicochemical properties of these receptor antagonists and in some cases provides orally bioavailable αvβ3 inhibitors.