Association between Serum Alanine Aminotransferase Level and Coronary Heart Disease

Objective To study the relationship between the serum alanine aminotransferase(ALT) level and coronary heart disease(CHD).Methods A total of 426 inpatients from the Second Hospital of Tianjin Medical University in 2011 were enrolled in this study and their serum ALT levels were determined and the coronary artery angiography was performed.Based on the results of coronary artery angiography,these patients were divided in the CHD group(n=294) and control group(n=132).The CHD group was further divided into three subgroups:single-branch subgroup(n=89),double-branch subgroup(n=91),and multiple-branch subgroup(n=114).The levels of serum ALT were compared among these groups.Results The serum ALT level was significantly higher in the CHD group than in the control group((23.4±18.7)U/L vs.(17.8±13.2)U/L,P0.01).The three subgroups also showed significantly different ALT level when compared with the control group(F=5.137,P=0.002).Multivariate Logistic regression analysis showed the higher serum ALT level was associated with the occurrence of CHD(OR=0.966,95%CI(0.944,0.988),P0.01).Conclusion CHD patients have higher serum ALT level than non-CHD patients.Serum ALT level can be used for predicting the severity of CHD.