A 12-month, multicenter, randomized, adaptive design, open-label study to evaluate the benefit of C2 hour monitoring of neoral on safety and efficacy outcomes in de novo cardiac transplant recipients receiving basiliximab induction

Marcelo Cantarovich,Heather J Ross,J M Arizon,M A Gomez,L Straatman,J Orus,Jonathan G Howlett,B Diaz,Susan Wang, L A Alonso Pulpon,Haissam Haddad,M Crespo,E Lage,N Manito

Journal of Heart and Lung Transplantation（2004）

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摘要

Cyclosporine (CsA) 2-hr post-dose level (C2) is the best single time point predictor of AUC and a critical measure for effective dosing.The therapeutic CsA microemulsion (Neoral) C2 range in de novo heart transplant (HTx) patients (pts) remains to be determined.

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c2 hour monitoring,open-label

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