Actions Of Insulin As A Survival And Growth Factor: Akt, Mtor, And Regulation Of Translation

Luc Furic,Mark Livingstone,Ivan Topisirovic,Nahum Sonenberg

INSULIN RESISTANCE AND CANCER: EPIDEMIOLOGY, CELLULAR AND MOLECULAR MECHANISMS AND CLINICAL IMPLICATIONS（2011）

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摘要

Binding of insulin to the insulin receptor (IR) stimulates the receptor’s tyrosine kinase activity. IR activation leads to the recruitment of key activators of downstream pathways via the insulin receptor substrate (IRS) proteins. In a similar fashion, the insulin growth factor-1 receptor (IGF1R) transduces signals to downstream effectors via the PI3K and MAPK pathways.

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