Mechanism Of Ectodomain Shedding Of Egfr Ligands By Il-1 Beta And Il-8 In Gastric Epithelial Cells

common genotype (52%) and hrgA/hrgB is least (4%) common, whereas in 42 Western strains hpyIIIR/hrgB (40%), and hrgA/hrgB (31%) are the most common.The 33 strains with iceA1 induced significantly more IL-8 (median 1483 pg/ml, range 287-2898) (p = 0.03) than 30 strains with hrgB (median 955 pg/ml, range 151-2452), whereas there was no difference in relation to the hpyIII locus.In Asian strains from gastric cancer patients (n=43, all cagA positive and vacA sl), 41% were hrgA and 20% were hrgB.This is an overrepresentation of hrgA, but not of hrgB, compared with non-gastric cancer diseases.Although gastric cancer strains from Western countries were not available for analysis, in patients with duodenal or gastric ulcer, hrgA but not hrgB was overrepresented (71%) compared to non-ulcer dyspepsia (39%, p<0.05) isolates.Conclusion: In this study, hrgA presence correlates with H. pylori clinical outcome, whereas iceA1 presence was associated with enhanced 1L-8 induction.