乳腺癌C-erbB-2和E-cadherin的表达与淋巴结转移的关系
Jiangsu Medical Journal(2013)
Abstract
目的 探讨乳腺癌组织人表皮生长因子受体2(C-erbB-2)和上皮性钙黏附素(E-cadherin)的表达与腋下淋巴结转移的关系.方法 根据腋下淋巴结转移情况,110例乳腺癌分为淋巴结无转移组(A组,70例)、淋巴结转移1-3个组(B组,17例)和淋巴结转移≥4个组(C组,23例),免疫组化法检测C-erbB-2和E-cadherin的表达.结果 A组C-erbB-2阳性率为37.1%,明显低于B组的64.7%和C组的91.3%(P<0.05和P<0.01),且C组明显高于B组(P<0.05).A组E-cadherin阳性率为74.3%,明显高于B组的47.1%和C组的17.4% (P<0.05和P<0.01),且C组明显低于B组(P<0.05).结论 乳腺癌组织C-erbB-2高表达和E-cadherin低表达者更易出现淋巴结转移.
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Key words
Lymph node metastasis,C-erbB-2,Breast cancer,E-cadherin
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