MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position.

A series of 2-carbon-substituted pyridopyrimidine derivatives were synthesized by palladium catalyzed cross-coupling reaction and evaluated for their ability to potentiate the activity of levofloxacin and aztreonam in Pseudomonas aeruginosa.