Research of glutamine and arginine on immunity and clinical effect for patients of lung cancer radiotherapy

Objective: The study was designed to observe the effect of glutamine and arginine in the patients of lung cancer radiotherapy.Methods: 36 cases diagnosed non-small cell lung cancer clinically were randomly divided into the radiotherapy group(n=18) and the combined treatment group(n=18).Radiotherapy group received radiotherapy alone.Combined treatment group received intravenous arginine and glutamine,Arg 25 g/d [0.5 g/(kg·d)],glutamine 20 g/d [0.4 g/(kg·d)] in 1~10 days while accepting radiotherapy.All patients were detected about ALB,PA,LC,CRP,complement C3,IgG and T cells Subsets CD3+,CD4+,CD8+ and CD4+/CD8+.Results: PA of the combined treatment group increased significantly P0.05 than in radiotherapy group.CD3+ and CD4+ cells in the combined treatment group increased and CD8+ cells decreased.Conclusion: Glutamine and arginine can increase CD4+/CD8+ in lung cancer radiotherapy,and enhance cellular immune function and nutritional status.