Oxyaniliniums as acetylcholinesterase inhibitors for the reversal of neuromuscular block
Bioorganic & Medicinal Chemistry Letters(2002)
摘要
A series of oxyanilinium-based AChE inhibitors have been synthesised and tested for the reversal of vecuronium-induced neuromuscular block. Several compounds, for example 2-hydroxy- and 2-methoxy-N,N-dimethyl-N-allylanilinium bromide (3 and 6) showed comparable reversal potencies to edrophonium and clean in vivo cardiovascular profiles.
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关键词
chemical synthesis,ether,cholinesterase,in vitro,in vivo,cat,enzyme
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