P.4.034 Neuropsychiatric symptoms in APOE genotyped Alzheimer's disease patients: Contributions to diagnosis and prognosis of the disease

Publisher SummaryThis chapter focuses on the clinical implications and limitations of magnetic resonance spectroscopy (MRS). It focuses primarily on determining what MRS can measure and the underlying MR physics of how this can be achieved. The chapter provides a detailed discussion on the biochemistry of the systems that determine the concentrations of substances that are measured by MRS. This information is essential for understanding and interpreting changes in the brain's chemistry. The chapter reviews the current state of literature in MRS of epilepsy and emphasizes its clinical applications. Moreover, improvements in MRS technology—such as the ability to calculate absolute concentrations, to account for differences between gray and white matter, and to achieve better spectral resolution by using a higher magnetic field strength—can lead to more extensive uses of MR techniques for patients with epilepsy.