顺铂、卡铂治疗晚期乳腺癌随机对照研究

Yan-fei LI,De-ming XU,Xiao-qiong ZHAO,Huan-wei CHEN,Hua-hai LING

Journal of Youjiang Medical College For Nationalities（2007）

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Abstract

目的探讨顺铂(PDD)、卡铂(CBP)治疗晚期乳腺癌临床应用效果及不良反应.方法 80例晚期乳腺癌随机分成NC组(40例)接受NC方案(盖诺+卡铂),NP组(40例)接受NP方案(盖诺+顺铂)治疗.结果 NC、NP组近期疗效(CR+PR)分别为42.50%、37.50%,两组差异无显著性(P＞0.05).NC组患者生存质量明显好于NP组(P＜0.05),NP组的Ⅲ度以上恶心、呕吐发生率比NC组高,NC组的Ⅲ～Ⅳ度骨髓抑制比NP组严重(P＜0.05),两组生存率相似.结论 NP方案和NC方案治疗晚期乳腺癌效果相近,生存率相似.但NC方案胃肠道反应轻,生存质量好,值得临床进一步推广.

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Key words

DDP,CBP,Navelbine,breast neoplasms

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